|
KMID : 1171820030180020060
|
|
Journal of Environmental and Sanitary Engineering
2003 Volume.18 No. 2 p.60 ~ p.66
|
|
|
Effects of molybdenum on myo-inositol uptake system in peripheral nerve isolated from lead-intoxicated rat
|
|
Song Jin-Ho
Chung Myung-Kiu
|
|
|
Abstract
|
|
|
|
This study was carried out to elucidate the preventive mechanism of molybdenum on lead-induced neuropathy. An animal model of lead neuropathy was induced by feeding diet containing lead to Sprague-Dawley rat for three weeks. Four weeks aged Sprague-Dawley rats were divided into four groups: normal control group. 10ppm-lead treated group. Img/kg-molybdenum treated group, 10ppm-lead and 1mg/kg-molybdenum treated group. The parameters on neuropathy were examined by measuring concentrdtion of myo-inositol and myo-inosito uptake in sciatic nerve. In the lead-treated rats, myo-inositol concentration and myo-inositol uptake rate were reduced by from 54% to 33% respectively. This deficit results from that myo-inositol uptake system which is canier mediated and sodium-potassium dependent was inhibited by the lead treatment. However, the molybdenum administration significantly eliminated the impairment and maintained myo-inositol concentration to about 82% of normal level. These results suggest that lead-induced neurotoxicity was significantly reduced by administration of molybdenum and the mechanism might be partly normalization of myo-inositol uptake system in sciatic nerve.
|
|
|
KEYWORD
|
|
|
molybdenum, lead, neurotoxicity, myo-inositol, myo-inositol uptake system
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|